H & A Pharma Shallaki Tablets

 

Shallaki is a formulation prepared from the oleo gum resin extract of Shallaki (Boswellia serrata) and Langali. Shallaki is recommended in the long-term management of different types of pain and inflammatory disorders associated with joints. Shallaki has antiarthritic, anti-inflammatory, and analgesic actions that suppress inflammatory mediators such as leukotrienes and 5-lipoxygenase (LOX). Shallaki exhibits an anti-inflammatory effect by considerably inhibiting the production of nitric oxide (NO), possibly through the suppression of inducible nitric oxide synthase (iNOS) mRNA expression. Shallaki significantly reduces the degradation of glycosaminoglycans (GAGs) that help protect cartilage.

Pharmacological Actions

1. Antiarthritic activity

Shallaki has been shown to have a beneficial effect on knee osteoarthritis. Boswellic acids exhibit an antiarthritic effect by inhibiting 5-LOX. Patients treated with Shallaki experience a significant decrease in joint pain, swelling, and increase in range of motion.

2. Anti-inflammatory activity

Proinflammatory cytokines such as tumor necrosis factor (TNF)-a, interleukin (IL)-13, and IL-6 play an important role in the modulation of acute and chronic inflammation. TNF-a is released early, in copious amounts, in response to a wide variety of invasive stimuli; overproduction of TNF-α has also been shown to induce the production of various inflammatory mediators such as cyclooxygenase-2, prostaglandin E2, reactive oxygen species, iNOS, IL-6, and NO. These mediators modulate important cellular events including gene expression, DNA damage, and cellular proliferation, which contribute to various inflammatory disorders. Therefore, cellular manipulation of the production of TNF-α and IL-13 is of importance for regulating the inflammatory response. Shallaki exhibits an anti-inflammatory effect by considerably inhibiting NO production, possibly through the suppression of iNOS mRNA expression and inhibition of TNF-a, IL-13, and IL-6.2

3. Cartilage-protective activity

Proinflammatory cytokines such as IL-13 and TNF-a destroy or kill the chondrocytes. IL-1ẞ is known to decrease synthesis of GAGs in articular cartilage, which is the nonprotein part of proteoglycan. Under inflammatory conditions, the chondrocytes and synovial cells produce a large amount of matrix metalloproteinases (MMPs), such as MMP3 and MMP13, which degrade the collagen matrix of the cartilage. Shallaki exhibits powerful anti-inflammatory and antiarthritic activities. Shallaki provides significantly better protection from IL-1B induced death of human primary chondrocytes and improves GAG production in human chondrocytes. Shallaki provides potential benefits in recovering ar articular cartilage damage or protection from proteolytic degradation by inhibiting MMP3 production

Indications

• Osteoarthritis 
• Rheumatoid arthritis 
• Back pain 
• Myalgia and arthralgia